聚前列腺素PGBx对线粒体保护机制的研究。
Studies on the mechanism of mitochondrial protection by polymeric prostaglandin PGBx.
作者信息
Shmukler H W, Zawryt M G, Soffer E F, Polis E, Feely W, Kwong S W, Cope F W
出版信息
Physiol Chem Phys. 1982;14(5):471-86.
On the basis of the interaction between tritiated PGBx and rat liver mitochondria, it appears that PGBx interacts with rat liver mitochondria to form a complex. At low PGBx-mitochondrial ratios, one effect of this complex formation is to stabilize the phosphorylation activity of rat liver mitochondria when exposed for short times to hypotonic solutions. At higher PGBx-mitochondrial ratios, PGBx fails to show this effect. At low PGBx concentrations, PGBx is also shown to inhibit release of amino acids and proteins as well as glutamic acid dehydrogenase and monoamine oxidase from the mitochondria and to inhibit mitochondrial swelling.
基于氚标记的PGBx与大鼠肝脏线粒体之间的相互作用，似乎PGBx与大鼠肝脏线粒体相互作用形成复合物。在低PGBx - 线粒体比例下，这种复合物形成的一个作用是，当大鼠肝脏线粒体短时间暴露于低渗溶液时，稳定其磷酸化活性。在较高的PGBx - 线粒体比例下，PGBx未显示出这种作用。在低PGBx浓度下，PGBx还被证明可抑制氨基酸和蛋白质的释放，以及线粒体中谷氨酸脱氢酶和单胺氧化酶的释放，并抑制线粒体肿胀。
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