Thompson W G, Gillies R R, Silver H K, Shuster J, Freedman S O, Gold P
Can Med Assoc J. 1974 Apr 6;110(7):775-7.
Sera were collected from 108 patients with inflammatory bowel disease and assayed for carcinoembryonic antigen (CEA) and alpha(1)-fetoprotein (AFP). Seven (14%) of 51 patients with ulcerative colitis had a positive test for CEA and one of these had associated carcinoma of the colon. Ten (19%) of 52 patients with regional enteritis were also seropositive. The sera of 4 (9%) of 47 patients with ulcerative colitis and 2 (5%) of 41 patients with regional enteritis contained small amounts of AFP. Of two unclassified patients one had a positive CEA and the other a positive AFP. No serum was positive for both CEA and AFP. In addition, multiple samples were available for sequential analysis in eight CEA-positive patients but there was no apparent relationship between seropositivity and disease activity. Continued follow-up is now in progress to determine the significance of detectable fetal antigen levels in inflammatory bowel disease.
从108例炎症性肠病患者中采集血清，检测癌胚抗原（CEA）和甲胎蛋白（AFP）。51例溃疡性结肠炎患者中有7例（14%）CEA检测呈阳性，其中1例伴有结肠癌。52例局限性肠炎患者中有10例（19%）血清学检测也呈阳性。47例溃疡性结肠炎患者中有4例（9%）血清含有少量AFP，41例局限性肠炎患者中有2例（5%）血清含有少量AFP。在2例未分类患者中，1例CEA呈阳性，另1例AFP呈阳性。没有血清CEA和AFP均呈阳性。此外，8例CEA阳性患者有多个样本可供连续分析，但血清阳性与疾病活动之间没有明显关系。目前正在继续随访，以确定炎症性肠病中可检测到的胎儿抗原水平的意义。
