热化学疗法：42至43摄氏度的高温与阿霉素（或博来霉素）在哺乳动物细胞失活中的协同作用。
Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.
作者信息
Hahn G M, Braun J, Har-Kedar I
出版信息
Proc Natl Acad Sci U S A. 1975 Mar;72(3):937-40. doi: 10.1073/pnas.72.3.937.
Abstract
The sensitivity of cells exposed in vitro to the antibiotics bleomycin or adriamycin is only mildly increased at 41 degrees over that seen at 37 degrees. However, at 43 degrees a marked synergism between the effects of hyperthermia and drug is observed. This synergism can also be demonstrated to occur in solid tumors in vivo. Cells after bleomycin exposure at 37 degrees repair potentially lethal damage, and 43 degrees inhibits this repair. This inhibition may in part account also for the observed sensitization of the cells to bleomycin, but not to adriamycin, since for the latter no repair can be demonstrated. However, fluorescence measurements show that at 43 degrees much more adriamycin is able to enter the cells than at 37 degrees. The possible implications of the results for cancer treatment are discussed.
摘要
体外暴露于抗生素博来霉素或阿霉素的细胞，在41摄氏度时的敏感性仅比37摄氏度时略有增加。然而，在43摄氏度时，观察到热疗和药物的作用之间存在明显的协同作用。这种协同作用在体内实体瘤中也能得到证实。在37摄氏度下暴露于博来霉素后的细胞会修复潜在的致死性损伤，而43摄氏度会抑制这种修复。这种抑制作用可能部分解释了观察到的细胞对博来霉素的敏感性增加，但对阿霉素不敏感，因为对于后者无法证明有修复作用。然而，荧光测量表明，在43摄氏度时，进入细胞的阿霉素比37摄氏度时多得多。文中讨论了这些结果对癌症治疗可能的影响。
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Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.热化学疗法：42至43摄氏度的高温与阿霉素（或博来霉素）在哺乳动物细胞失活中的协同作用。
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