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戊巴比妥麻醉对犬细胞外液容量和成分的影响。

The effects of pentobarbitone anaesthesia on the volume and composition of the extracellular fluid of dogs.

作者信息

Rampton D S, Ramsay D J

出版信息

J Physiol. 1974 Mar;237(3):521-33. doi: 10.1113/jphysiol.1974.sp010496.

Abstract
  1. The effects of pentobarbitone sodium (Nembutal) anaesthesia in dogs on extracellular fluid and plasma volumes, plasma protein concentration, haematocrit and extracellular fluid electrolyte composition were measured.2. Induction of pentobarbitone anaesthesia caused a rapid rise in extracellular fluid volume, accompanied by decreases in the haematocrit, in extracellular fluid potassium concentration, and in plasma calcium, magnesium, and protein concentrations. There were no significant changes in plasma osmolality and extracellular fluid concentrations of sodium and chloride.3. Extracellular fluid volume did not alter significantly during six hours of anaesthesia, but the haematocrit and extracellular fluid potassium concentration showed an increase towards control values.4. The relevance of these findings to the interpretation of experiments carried out under pentobarbitone anaesthesia is noted.
摘要
  1. 测定了戊巴比妥钠(速可眠)麻醉对犬细胞外液和血浆容量、血浆蛋白浓度、血细胞比容及细胞外液电解质组成的影响。

  2. 戊巴比妥麻醉诱导导致细胞外液容量迅速增加,同时伴有血细胞比容、细胞外液钾浓度、血浆钙、镁和蛋白浓度降低。血浆渗透压以及细胞外液钠和氯浓度无显著变化。

  3. 麻醉6小时期间细胞外液容量无显著改变,但血细胞比容和细胞外液钾浓度向对照值升高。

  4. 注意到这些发现与对在戊巴比妥麻醉下进行的实验的解释的相关性。

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