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Acid base status in unanesthetized, unrestrained guinea pigs.

作者信息

Bar-Ilan A, Marder J

出版信息

Pflugers Arch. 1980 Mar;384(1):93-7. doi: 10.1007/BF00589520.

DOI:10.1007/BF00589520
PMID:6770339
Abstract

Acid-base status of arterial blood was measured in chronically cannulated, unanesthetized, unrestrained guinea pigs. Normal values were: pH = 7.444 +/- 0.032; PaCO2 = 35.7 +/- 4.4; HCO3- = 24.4 +/- 2.8; BE = +0.4 +/- 2.1 (n = 69) and PaCO2 = 91.9 +/- 7.3 (n = 25) (Values are mean +/- S.D.). Induction of light anesthesia with thiopentone caused a respiratory depression (decrease in PaO2) accompanied by respiratory acidosis (increase in PaCO2 and decrease in pH) and a development of slight metabolic acidosis (decrease in base excess and standard bicarbonate). Acid base parameters of guinea pigs are compared to those obtained from rats under identical experimental conditions.

摘要

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本文引用的文献

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Routine direct measurement of arterial pressure in unanesthetized rats.未麻醉大鼠动脉压的常规直接测量。
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Lipoxygenase metabolites mediate increased airways responsiveness to histamine after acute platelet activating factor exposure in the guinea-pig.在豚鼠中，脂氧合酶代谢产物介导急性血小板活化因子暴露后气道对组胺反应性的增加。
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