van Ooyen A, van den Berg J, Mantei N, Weissmann C
Science. 1979 Oct 19;206(4416):337-44. doi: 10.1126/science.482942.
The nucleotide sequence of a cloned rabbit chromosomal DNA segment of 1620 nucleotides length which contains a beta-globin gene is presented. The coding regions are separated into three blocks by two intervening sequences of 126 and 573 base pairs, respectively. The rabbit sequence was compared with a homologous mouse sequence. The segments flanking the rabbit gene, as well as the coding regions, the 5' noncoding and part of the 3' noncoding messenger RNA sequences are similar to those of the mouse gene; the homologous introns, despite identical location, are distinctly dissimilar except for the junction regions. Homologous introns may be derived from common ancestral introns by large insertions and deletions rather than be multiple point mutations.
本文展示了一段长度为1620个核苷酸的克隆兔染色体DNA片段的核苷酸序列，该片段包含一个β-珠蛋白基因。编码区被两个分别为126和573个碱基对的间隔序列分隔成三个区域。将兔的序列与同源的小鼠序列进行了比较。兔基因两侧的片段以及编码区、5'非编码区和部分3'非编码信使RNA序列与小鼠基因的相似；同源内含子尽管位置相同，但除连接区域外明显不同。同源内含子可能是通过大量的插入和缺失而非多点突变从共同的祖先内含子衍生而来。
