克隆兔和小鼠β-珠蛋白基因的比较显示出两对同源内含子的强烈进化差异。
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns.
作者信息
van den Berg J, van Ooyen A, Mantei N, Schamböck A, Grosveld G, Flavell R A, Weissmann C
出版信息
Nature. 1978 Nov 2;276(5683):37-44. doi: 10.1038/276037a0.
DOI:10.1038/276037a0
PMID:264241
Abstract
Cloned beta-globin genes of both mouse and rabbit each contain a large and a small intervening sequence (intron) of about equal length at precisely the same positions relative to the coding sequence. The homologous introns show some sequence similarity, particularly at the junctions with the coding sequence. They most probably arose from a common ancestral sequence and diverged substantially during evolution.
摘要
小鼠和兔子的克隆β-珠蛋白基因在相对于编码序列的精确相同位置，各自都包含一个大约等长的大的和小的间隔序列（内含子）。同源内含子显示出一些序列相似性，特别是在与编码序列的连接处。它们很可能起源于一个共同的祖先序列，并在进化过程中发生了显著分歧。
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