姜片吸虫病患者的血清维生素B12和叶酸水平

Serum vitamin B 12 and folic acid levels in patients with fasciolopsiasis.

作者信息

Areekul S, Jaroonvesama N, Charoenlarp K, Kasemsuth R, Cheeramakara C

出版信息

Southeast Asian J Trop Med Public Health. 1979 Mar;10(1):67-72.

Abstract

Serum vitamin B12, serum and red cell folate concentrations and vitamin B12 absorption were studied in 100 patients with fasciolopsiasis. A mean value of serum vitamin B12 level in the patient group was found to be significantly lower than that of normal subjects and 14% of these patients had serum vitamin B12 level less than 100 pg/ml. Serum UBBC and TBBC levels in the patients were significantly higher than those of the normal subjects. Serum TCI and TCIII increased significantly while TCII decreased. Vitamin B12 absorption was found to be impaired in 3 of 9 patients studied. There was no relationship seen between serum vitamin B12 level and vitamin B12 absorption. The mean values of serum folate and red cell folate levels in the patient group were significantly lower than those of normal subjects. Fifteen of 100 patients (15%) had serum folate level less than 3 ng/ml, while all of them had red cell folate higher than 100 ng/ml. Serum folic acid binding protein levels (FABP) in these patients, were not significantly different from those of normal subjects.

摘要

对100例姜片吸虫病患者的血清维生素B12、血清及红细胞叶酸浓度和维生素B12吸收情况进行了研究。发现患者组血清维生素B12水平的平均值显著低于正常受试者，且这些患者中有14%的血清维生素B12水平低于100 pg/ml。患者的血清未结合维生素B12（UBBC）和总结合维生素B12（TBBC）水平显著高于正常受试者。血清转钴胺素I（TCI）和转钴胺素III（TCIII）显著升高，而转钴胺素II（TCII）降低。在所研究的9例患者中，有3例维生素B12吸收受损。血清维生素B12水平与维生素B12吸收之间未见相关性。患者组血清叶酸和红细胞叶酸水平的平均值显著低于正常受试者。100例患者中有15例（15%）血清叶酸水平低于3 ng/ml，而他们所有人的红细胞叶酸均高于100 ng/ml。这些患者的血清叶酸结合蛋白水平（FABP）与正常受试者无显著差异。