Areekul S, Hathirat P, Churdchu K
Southeast Asian J Trop Med Public Health. 1986 Jun;17(2):184-8.
Serum vitamin B12, serum and red cell folate and serum vitamin B12 binding proteins were determined in 18 patients with neuroblastoma, with ages ranging from 8 months to 14 years. A mean value of serum vitamin B12 level was slightly but not significantly lower than that of the normal subjects but all of them had serum vitamin B12 levels over 150 pg/ml. There was no relationship between serum vitamin B12 levels and hemoglobin, hematocrit or white cells. Transcobalamin I (TCI) was significantly increased resulting in slightly elevated UBBC and normal TBBC levels in these patients. This could be a compensatory mechanism for the low serum vitamin B12 by increasing the unsaturated vitamin B12 binding capacity of TCI. All these findings indicated that the status of vitamin B12 in patients with neuroblastoma was within the normal limits. Treatment of neuroblastoma by giving a high dose of vitamin B12 would therefore not give any direct therapeutic effect. Both serum and red cell folate concentrations were significantly lower in the group of patients. As only 2 out of 18 patients had low serum folate and none of them had red cell folate lower than the lower limit of normal subjects; therefore these patients were only in the state of negative folate balance.
对18例年龄在8个月至14岁之间的神经母细胞瘤患者测定了血清维生素B12、血清和红细胞叶酸以及血清维生素B12结合蛋白。血清维生素B12水平的平均值略低于正常受试者，但差异无统计学意义，且所有患者的血清维生素B12水平均超过150 pg/ml。血清维生素B12水平与血红蛋白、血细胞比容或白细胞之间无相关性。这些患者的转钴胺素I（TCI）显著升高，导致未饱和维生素B12结合能力（UBBC）略有升高，总结合能力（TBBC）正常。这可能是通过增加TCI的不饱和维生素B12结合能力来补偿低血清维生素B12的一种机制。所有这些发现表明神经母细胞瘤患者的维生素B12状态在正常范围内。因此，给予高剂量维生素B12治疗神经母细胞瘤不会产生任何直接治疗效果。该组患者的血清和红细胞叶酸浓度均显著降低。由于18例患者中只有2例血清叶酸水平低，且无一例患者的红细胞叶酸水平低于正常受试者的下限；因此，这些患者仅处于叶酸负平衡状态。
