青霉素6-α位取代和头孢菌素7-β位取代对β-内酰胺反应活性的影响。 - Suppr

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超能文献

Effect of 6-alpha substitution in penicillins and 7-beta substitution in cephalosporins upon beta-lactam reactivity.

作者信息

Indelicato J M, Wilham W L

出版信息

J Med Chem. 1974 May;17(5):528-9. doi: 10.1021/jm00251a012.

DOI:10.1021/jm00251a012

PMID:4830255

Abstract

摘要

相似文献

Effect of 6-alpha substitution in penicillins and 7-beta substitution in cephalosporins upon beta-lactam reactivity.青霉素6-α位取代和头孢菌素7-β位取代对β-内酰胺反应活性的影响。

J Med Chem. 1974 May;17(5):528-9. doi: 10.1021/jm00251a012.

Substituent effects upon the base hydrolysis of penicillins and cephalosporins. Competitive intramolecular nucleophilic amino attack in cephalosporins.

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Electronic structures of cephalosporins and penicillins. 4. Modeling acylation by the beta-lactam ring.头孢菌素和青霉素的电子结构。4. β-内酰胺环酰化作用的建模

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CNDO-2 study of the antibacterial activity of penicillins and cephalosporins.

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Substituent effects in cephalosporins as assessed by molecular orbital calculations, nuclear magnetic resonance, and kinetics.通过分子轨道计算、核磁共振和动力学评估头孢菌素中的取代基效应。

J Med Chem. 1983 Jul;26(7):1010-3. doi: 10.1021/jm00361a013.

Electronic structures of cephalosporins and penicillins. 2. Disulfide and beta-lactam chromophores. Structure-activity relationships.头孢菌素和青霉素的电子结构。2. 二硫键和β-内酰胺发色团。构效关系。

J Med Chem. 1973 Nov;16(11):1195-9. doi: 10.1021/jm00269a001.

Delta 2- and delta 3-cephalosporins, penicillinate and 6-unsubstituted penems. Intrinsic reactivity and interaction with beta-lactamases and D-alanyl-D-alanine-cleaving serine peptidases.δ2-和δ3-头孢菌素、青霉素酸盐及6-未取代青霉烯。内在反应活性以及与β-内酰胺酶和D-丙氨酰-D-丙氨酸裂解丝氨酸肽酶的相互作用。

Biochem J. 1982 Apr 1;203(1):223-34. doi: 10.1042/bj2030223.

Substituent effects on reactivity and spectral parameters of cephalosporins.取代基对头孢菌素反应活性和光谱参数的影响。

J Med Chem. 1984 May;27(5):694-700. doi: 10.1021/jm00371a025.

Theoretical studies on beta-lactam antibiotics. I. Conformational similarity of penicillins and cephalosporins to X-D-alanyl-D-alanine and correlation of their structure with activity.β-内酰胺抗生素的理论研究。I. 青霉素和头孢菌素与X-D-丙氨酰-D-丙氨酸的构象相似性及其结构与活性的相关性。

Int J Pept Protein Res. 1977;10(1):51-9.

Nocardicin A, a new monocyclic beta-lactam antibiotic II. Structure determination of nocardicins A and B.

J Antibiot (Tokyo). 1976 Sep;29(9):890-901. doi: 10.7164/antibiotics.29.890.

引用本文的文献

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Role of the 7 alpha-methoxy and side-chain carboxyl of moxalactam in beta-lactamase stability and antibacterial activity.羟羧氧酰胺菌素的7α-甲氧基和侧链羧基在β-内酰胺酶稳定性及抗菌活性中的作用

Antimicrob Agents Chemother. 1981 Jan;19(1):1-7. doi: 10.1128/AAC.19.1.1.

Penicillins and cephalosporins. Physicochemical properties and analysis in pharmaceutical and biological matrices.青霉素和头孢菌素。药物及生物基质中的物理化学性质与分析

Pharm Weekbl Sci. 1987 Feb 20;9(1):1-23. doi: 10.1007/BF01956487.

Cephamycins: a review, prospects and some original observations.头孢霉素：综述、前景及一些原创性观察

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Substrate inhibition of beta-lactamases, a method for predicting enzymatic stability of cephalosporins.β-内酰胺酶的底物抑制作用，一种预测头孢菌素酶稳定性的方法。

Antimicrob Agents Chemother. 1976 Sep;10(3):470-5. doi: 10.1128/AAC.10.3.470.

Transition state structures of a dipeptide related to the mode of action of beta-lactam antibiotics.与β-内酰胺类抗生素作用模式相关的二肽的过渡态结构。

Proc Natl Acad Sci U S A. 1977 Dec;74(12):5239-43. doi: 10.1073/pnas.74.12.5239.

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