Meurman L O, Kiviluoto R, Hakama M
Br J Ind Med. 1974 Apr;31(2):105-12. doi: 10.1136/oem.31.2.105.
105-112. A study has been made in Finland of the effects of anthophyllite asbestos on mortality and morbidity of 1 092 asbestos workers first employed at two mines between 1936 and 1969; 95% of workers were traced, 248 of whom had died. A similar number of age-sex-matched controls was selected from a township 60 km from the mines. The causes of death included an excess due to lung cancer and asbestosis, but cancers of the digestive system occurred in equal frequency, and neither the cases nor controls had any confirmed mesotheliomas. Assuming a multiplicative effect of asbestos and smoking, the relative risk of lung cancer was 17 for an asbestos worker who smokes in terms of a non-exposed non-smoker. The corresponding figures were 12 for a smoker without asbestos exposure and 1·4 for an asbestos worker who did not smoke. More heavy smokers were found among the asbestos workers than among the controls. A threefold excess of dyspnoea and a twofold excess of cough were recorded for the asbestos workers compared with the controls after adjustment for smoking.
105 - 112。芬兰对1936年至1969年间首次受雇于两座矿山的1092名石棉工人进行了一项研究,以探讨直闪石石棉对其死亡率和发病率的影响;95%的工人被追踪到,其中248人已经死亡。从距离矿山60公里的一个城镇中选取了数量相近的年龄 - 性别匹配的对照组。死亡原因包括肺癌和石棉沉着病导致的超额死亡,但消化系统癌症的发生频率相同,病例组和对照组均未确诊间皮瘤。假设石棉和吸烟存在相乘效应,对于吸烟的石棉工人而言,相对于未接触石棉且不吸烟的人,患肺癌的相对风险为17。对于未接触石棉的吸烟者,相应数字为12,对于不吸烟的石棉工人,相应数字为1.4。在石棉工人中发现的重度吸烟者比对照组多。在对吸烟进行调整后,与对照组相比,石棉工人的呼吸困难发生率高出三倍,咳嗽发生率高出两倍。