Jancloes M F, Cornet P, Thienpont D
Trop Geogr Med. 1979 Mar;31(1):111-21.
Ninety-, 60-, and 40-percent population coverages with levamisole 2.5 mg/kg of body weight were compared for their effects on Ascaris lumbricoides, ancylostoma, Strongyloides stercoralis, and Trichuris trichiura infections. They were shown to be effective in maintaining a reduced prevalence of A. lumbricoides in the treated subjects for 9, 6, and 3 months, respectively. Nine months after treatment, the prevalence of ascariasis was still lower than before treatment both in the levamisole and in the control subjects, regardless of the population coverage. This was probably because the egg output had been reduced. It is concluded that mass treatment with single oral doses of levamisole repeated at 3-month intervals might help control ascariasis, and that population coverages between 60 and 90% might be appropriate. No clear-cut effects against hookworms could be shown, possibly because the first follow-up examinations were performed three months after treatment. No changes in the prevalence of S. stercoralis and T. trichiura could be demonstrated. There were no adverse exp
比较了左旋咪唑按体重2.5毫克/千克给予90%、60%和40%人群覆盖率时，对蛔虫、钩虫、粪类圆线虫和鞭虫感染的影响。结果显示，它们分别能在治疗对象中使蛔虫感染率降低的状态维持9个月、6个月和3个月。治疗9个月后，无论人群覆盖率如何，左旋咪唑治疗组和对照组的蛔虫病感染率仍低于治疗前。这可能是因为虫卵排出量减少了。结论是，每3个月间隔单次口服左旋咪唑进行群体治疗可能有助于控制蛔虫病，60%至90%的人群覆盖率可能是合适的。未显示出对钩虫有明确效果，可能是因为首次随访检查是在治疗后3个月进行的。未证明粪类圆线虫和鞭虫的感染率有变化。未出现不良……（原文此处不完整）
