Liakakos D, Ikkos D G, Vlachos P, Ntalles K, Coulouris C
Arch Dis Child. 1974 May;49(5):400-3. doi: 10.1136/adc.49.5.400.
Oral administration of ascorbic acid, 0·5 g every 8 hours for a period of 4 days, had no effect on the urinary hydroxyproline excretion of 7 healthy children aged 8 to 14 years. When the same medication was given to 8 children aged 9 to 14 years who were receiving large doses of prednisolone (2 mg/kg per 24 hr) for a period of at least 15 days before as well as during ascorbic acid administration, a rise in the urinary hydroxyproline excretion was observed (from a mean value of 44±4·1 SE before to 67±4·6 mg/24 hr on the 4th day of ascorbic acid administration, P <0·001). Urinary hydroxyproline excretion of 3 children 4 days after stopping ascorbic acid administration, while still on prednisolone, had returned to the level observed before ascorbic acid. It is concluded that large doses of ascorbic acid can, under acute conditions, neutralize the inhibitory action of corticosteroids on new collagen formation.
对7名8至14岁的健康儿童口服抗坏血酸，每8小时0.5克，持续4天，对其尿羟脯氨酸排泄没有影响。当对8名9至14岁的儿童给予相同药物时，这些儿童在抗坏血酸给药前以及给药期间至少15天一直在接受大剂量泼尼松龙（每24小时2毫克/千克）治疗，观察到尿羟脯氨酸排泄增加（抗坏血酸给药前平均值为44±4.1标准误，给药第4天升至67±4.6毫克/24小时，P<0.001）。在停止抗坏血酸给药4天后，3名仍在服用泼尼松龙的儿童的尿羟脯氨酸排泄已恢复到抗坏血酸给药前观察到的水平。得出的结论是，在急性条件下，大剂量抗坏血酸可以抵消皮质类固醇对新胶原形成的抑制作用。
