Liakakos D, Vlachos P, Doulas N L, Litsios B, Alexiou D
Dev Pharmacol Ther. 1981;2(2):69-79.
The effect of excess ascorbic acid on the epiphyseal plate of young guinea pigs receiving prednisolone over a period of 28 days has been investigated. The results show that the structural and morphologic changes caused in the epiphyseal plate of the animals receiving prednisolone are prevented by the simultaneous administration of excess ascorbic acid. These data are consistent with the hypothesis that pharmacological doses of ascorbic acid given concurrently to children receiving prolonged treatment with corticosteroids may prevent suppression of growth in these children.
研究了过量抗坏血酸对接受泼尼松龙治疗28天的幼年豚鼠骨骺板的影响。结果表明，同时给予过量抗坏血酸可预防接受泼尼松龙治疗的动物骨骺板出现的结构和形态学变化。这些数据与以下假设一致：在接受长期皮质类固醇治疗的儿童中同时给予药理剂量的抗坏血酸可能会预防这些儿童的生长抑制。
