Styles J A
Br J Exp Pathol. 1974 Feb;55(1):71-7.
Paraquat and diquat are of similar toxicity to rat alveolar and peritoneal macrophages in tissue culture. Irreversible damage to macrophages occurs after exposure of 30 min to paraquat or diquat at concentrations as low as 10 mol/l, resulting in the uptake of vital dye. Paraquat and diquat at concentrations of 10 mol/l or less do not reduce viability of fibroblasts as measured by dye exclusion but reduce cloning efficiency. The toxicity of diquat to fibroblasts is approximately ten-fold greater than that of paraquat.
在组织培养中，百草枯和敌草快对大鼠肺泡巨噬细胞和腹腔巨噬细胞具有相似的毒性。在低至10摩尔/升的浓度下，巨噬细胞暴露于百草枯或敌草快30分钟后会发生不可逆损伤，导致摄取活性染料。浓度为10摩尔/升或更低的百草枯和敌草快不会像通过染料排斥法测量的那样降低成纤维细胞的活力，但会降低克隆效率。敌草快对成纤维细胞的毒性比对百草枯的毒性大约高十倍。
