长期饥饿时的能量供应、组织利用及体重减轻
Energy provision, tissue utilization, and weight loss in prolonged starvation.
作者信息
Runcie J, Hilditch T E
出版信息
Br Med J. 1974 May 18;2(5915):352-6. doi: 10.1136/bmj.2.5915.352.
Daily weight loss measurements in 76 fasting, obese patients (58 females, 18 males) have shown a characteristic pattern of rapid loss initially (up to day 14) followed by a slower but uniform reduction in weight. There were significant sex differences. Measurements of tissue breakdown showed that the initial rapid weight loss was due to the continuing utilization by the nervous system of glucose derived from lean tissue. This requirement fell noticeably from the second week of starvation. Irreversible fluid elimination also contributed to the initial phase of rapid weight loss. Fat remained the primary source of energy throughout starvation and in established fasting (more than 14 days) contributed 96% of that requirement.
对76名肥胖的禁食患者（58名女性，18名男性）进行的每日体重测量显示，最初（直至第14天）体重快速下降，之后体重下降速度放缓但较为均匀，呈现出一种特征性模式。存在显著的性别差异。组织分解测量表明，最初的快速体重下降是由于神经系统持续利用来自瘦组织的葡萄糖。从饥饿第二周起，这种需求明显下降。不可逆转的液体流失也促成了体重快速下降的初始阶段。在整个饥饿期间，脂肪一直是主要能量来源，在长期禁食（超过14天）时，脂肪提供了96%的能量需求。
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