多发性硬化症中获得性摆动性眼球震颤伴视振荡：小脑核疾病的一种体征。
Acquired pendular nystagmus with oscillopsia in multiple sclerosis: a sign of cerebellar nuclei disease.
作者信息
Aschoff J C, Conrad B, Kornhuber H H
出版信息
J Neurol Neurosurg Psychiatry. 1974 May;37(5):570-7. doi: 10.1136/jnnp.37.5.570.
In an unselected series of 644 cases of multiple sclerosis, 25 cases with acquired pendular nystagmus were found. Ten additional cases of pendular nystagmus in multiple sclerosis were investigated, and four cases from the literature are analysed. Acquired pendular nystagmus is purely sinusoidal in form, ceases with eye closure, is accompanied by oscillopsia, often monocular and vertical in direction, and never accompanied by optokinetic inversion. This is different from congenital nystagmus. Acquired pendular nystagmus in multiple sclerosis shows a high correlation with holding tremor of head and arm and with trunk ataxia, and must therefore be viewed as a result of lesions of cerebellar nuclei or their fibre connections with the brain-stem. Supporting evidence is discussed. The results fit into a theory of cerebellar function according to which the cerebellar nuclei are involved in the maintenance of positions.
在一组未经挑选的644例多发性硬化症病例中，发现25例患有后天性钟摆型眼球震颤。另外对10例多发性硬化症伴钟摆型眼球震颤的病例进行了研究，并分析了文献中的4例病例。后天性钟摆型眼球震颤呈纯正弦波形，闭眼时停止，伴有视振荡，通常为单眼且方向垂直，从不伴有视动性反转。这与先天性眼球震颤不同。多发性硬化症中的后天性钟摆型眼球震颤与头部、手臂的持物震颤以及躯干共济失调高度相关，因此必须被视为小脑核或其与脑干的纤维连接受损的结果。文中讨论了支持证据。这些结果符合一种小脑功能理论，即小脑核参与维持身体姿势。
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