Barton J J, Cox T A
Canada Division of Neurology, University of British Columbia, Vancouver, BC.
J Neurol Neurosurg Psychiatry. 1993 Mar;56(3):262-7. doi: 10.1136/jnnp.56.3.262.
Thirty seven patients with pendular nystagmus due to multiple sclerosis were reviewed. Most developed nystagmus later in a progressive phase of the disease. All had cerebellar signs on examination and evidence of optic neuropathy. MRI in eight patients showed cerebellar or brainstem lesions in seven; the most consistent finding was a lesion in the dorsal pontine tegmentum. Dissociated nystagmus was seen in 18 patients: in these the signs of optic neuropathy were often asymmetric and the severity correlated closely with the side with larger oscillations. This suggests that dissociations in acquired pendular nystagmus may be due to asymmetries in optic neuropathy rather than asymmetries in cerebellar or brainstem disease.
对37例因多发性硬化症导致钟摆型眼球震颤的患者进行了回顾性研究。大多数患者在疾病的进展期较晚出现眼球震颤。所有患者检查时均有小脑体征及视神经病变的证据。8例患者的MRI显示，7例有小脑或脑干病变；最常见的发现是脑桥背侧被盖部病变。18例患者出现分离性眼球震颤：在这些患者中，视神经病变的体征往往不对称，且严重程度与摆动幅度较大一侧密切相关。这表明后天性钟摆型眼球震颤的分离可能是由于视神经病变的不对称，而非小脑或脑干疾病的不对称。
