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1
Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.麦角胺和甲基麦角新碱对偏头痛患者血小板聚集反应的影响。
J Neurol Neurosurg Psychiatry. 1974 May;37(5):593-7. doi: 10.1136/jnnp.37.5.593.
2
5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache.急性偏头痛患者的5-羟色胺水平及血小板聚集反应
J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):505-9. doi: 10.1136/jnnp.35.4.505.
3
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J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):711-4. doi: 10.1136/jnnp.37.6.711.
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Effects of methysergide on platelets incubated with reserpine.甲基麦角新碱对与利血平一起孵育的血小板的作用。
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6
Dihydroergotamine, ergotamine, methysergide and sumatriptan - basic science in relation to migraine treatment.二氢麦角胺、麦角胺、麦角乙脲和舒马曲坦——与偏头痛治疗相关的基础科学。
Headache. 2012 Apr;52(4):707-14. doi: 10.1111/j.1526-4610.2012.02124.x. Epub 2012 Mar 22.
7
An assessment of platelet aggregation induced by 5-hydroxytryptamine.5-羟色胺诱导的血小板聚集评估。
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10
Migraine in childhood. Brief review of this inherited disorder which strikes five per cent of school-age children.儿童偏头痛。对这种遗传性疾病的简要综述，该病影响5%的学龄儿童。
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[Clinical aspects of pathophysiological mechanisms in migraine.].[偏头痛病理生理机制的临床方面。]
Schmerz. 1989 Dec;3(4):180-8. doi: 10.1007/BF02527377.
2
Measurement of activity of 5-HT antagonists following oral administration in man: a comparison of methysergide and BW501.人口服给药后5-羟色胺拮抗剂活性的测定：麦角新碱与BW501的比较
Br J Clin Pharmacol. 1979 Feb;7(2):197-9. doi: 10.1111/j.1365-2125.1979.tb00921.x.

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[THE "THRESHOLD OF SENSITIVITY TO SEROTONIN" IN NORMAL AND PATHOLOGIC CONDITIONS. PRELIMINARY NOTE].[正常及病理状态下“血清素敏感性阈值”。初步报告]
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CLINICAL TRIAL OF METHYSERGIDE AND OTHER PREPARATIONS IN THE MANAGEMENT OF MIGRAINE.麦角新碱及其他制剂治疗偏头痛的临床试验
J Neurol Neurosurg Psychiatry. 1964 Oct;27(5):463-9. doi: 10.1136/jnnp.27.5.463.
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ESTIMATION OF 5-HYDROXYTRYPTAMINE IN HUMAN BLOOD.人体血液中5-羟色胺的测定
Clin Chim Acta. 1964 Apr;9:364-9. doi: 10.1016/0009-8981(64)90027-0.
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METHYSERGIDE FOR PREVENTION OF HEADACHE; EXPERIENCE IN FIVE HUNDRED PATIENTS OVER THREE YEARS.麦角乙脲预防头痛；三年来五百例患者的经验
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[Effect of ergotamine tartrate on urinary excretion of 5-hydroxyindoleacetic acid].
Boll Soc Ital Biol Sper. 1967 Mar 31;43(6):308-10.
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Effect of Serpasil, Niamid and Deseril on the excretion of 5-hydroxyindoloacetic acid in diurnal urine and on oxidase activity of ceruloplasmin in human serum.利血平、尼亚酰胺和地昔帕明对人日间尿中5-羟吲哚乙酸排泄及人血清铜蓝蛋白氧化酶活性的影响。
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Effects of 5-hydroxytryptamine on platelet aggregation.5-羟色胺对血小板聚集的影响。
Nature. 1968 Apr 13;218(5137):137-41. doi: 10.1038/218137a0.
8
An assessment of platelet aggregation induced by 5-hydroxytryptamine.5-羟色胺诱导的血小板聚集评估。
J Clin Pathol. 1971 Apr;24(3):250-8. doi: 10.1136/jcp.24.3.250.
9
[Total blood serotonin content in migraine patients during attacks and in the period between attacks].[偏头痛患者发作期间及发作间期的全血血清素含量]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1969;69(6):831-5.
10
Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid excretion in normal and migrainous subjects.正常人和偏头痛患者的血浆总血清素、5-羟吲哚乙酸及对羟基间甲氧基扁桃酸排泄情况。
Brain. 1965 Dec;88(5):997-1010. doi: 10.1093/brain/88.5.997.

麦角胺和甲基麦角新碱对偏头痛患者血小板聚集反应的影响。

Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.

作者信息

Hilton B P, Zilkha K J

出版信息

J Neurol Neurosurg Psychiatry. 1974 May;37(5):593-7. doi: 10.1136/jnnp.37.5.593.

DOI:10.1136/jnnp.37.5.593
PMID:4836755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494705/
Abstract

Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.

摘要

在服用马来酸美西麦角或酒石酸麦角胺的偏头痛患者的血浆中，测量了血小板对5-羟色胺（5-HT）的聚集反应，发现该反应降低。无头痛症状的受试者的血液5-HT水平不受这些药物影响。这些结果支持了以下假说：美西麦角和麦角胺通过占据血管壁中的5-HT摄取位点起作用，使5-HT分子可用于占据与血管收缩有关的受体。