甲基麦角新碱对与利血平一起孵育的血小板的作用。
Effects of methysergide on platelets incubated with reserpine.
作者信息
Cumings J N, Hilton B P
出版信息
Br J Pharmacol. 1971 Aug;42(4):611-9. doi: 10.1111/j.1476-5381.1971.tb07145.x.
Abstract
- Platelets were incubated with methysergide and related compounds (2-bromo lysergic acid (BOL), ergotamine and methyl ergotamine) together with reserpine.2. Methysergide inhibited the normal aggregation response of platelets to 5-hydroxytryptamine (5HT) but did not affect the reduction in the 5HT content caused by reserpine, or the uptake of 5HT by the platelets.3. BOL, ergotamine and methyl ergotamine behaved similarly. Methysergide had greater anti5HT potency than BOL, and methyl ergotamine had greater potency than ergotamine.4. The use of platelets as a model for synaptic preparations is discussed.5. The role of 5HT receptor sites on the platelet membrane and the significance of the results for migraine patients treated with methysergide are discussed.
摘要
将血小板与甲基麦角新碱及相关化合物（2-溴麦角酸（BOL）、麦角胺和甲基麦角胺）以及利血平一起孵育。
甲基麦角新碱抑制血小板对5-羟色胺（5HT）的正常聚集反应，但不影响利血平引起的5HT含量降低，也不影响血小板对5HT的摄取。
BOL、麦角胺和甲基麦角胺表现相似。甲基麦角新碱的抗5HT效力比BOL更强，甲基麦角胺的效力比麦角胺更强。
讨论了将血小板用作突触制剂模型的用途。
讨论了血小板膜上5HT受体位点的作用以及这些结果对用甲基麦角新碱治疗的偏头痛患者的意义。
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Effects of methysergide on platelets incubated with reserpine.甲基麦角新碱对与利血平一起孵育的血小板的作用。
Br J Pharmacol. 1971 Aug;42(4):611-9. doi: 10.1111/j.1476-5381.1971.tb07145.x.
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引用本文的文献
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J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):711-4. doi: 10.1136/jnnp.37.6.711.
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Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.麦角胺和甲基麦角新碱对偏头痛患者血小板聚集反应的影响。
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A COMPARISON OF PLATELET AGGREGATION PRODUCED BY SEVEN COMPOUNDS AND A COMPARISON OF THEIR INHIBITORS.七种化合物所产生的血小板聚集的比较及其抑制剂的比较。
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Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat's paw by serotonin.麦角酸衍生物与抗组胺药作为5-羟色胺诱发大鼠爪部水肿抑制剂的比较
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Antagonism by methysergide of vascular effects of 5-hydroxytryptamine in man.甲基麦角新碱对人体5-羟色胺血管效应的拮抗作用。
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