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利血平和氯丙嗪对偏头痛患者及对照者血小板摄取5-羟色胺的影响。

Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.

作者信息

Hilton B P

出版信息

J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):711-4. doi: 10.1136/jnnp.37.6.711.

DOI:10.1136/jnnp.37.6.711
PMID:4844137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC494752/
Abstract

Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascular receptors causing constriction and are distinct from those transferring 5-HT through the platelet membrane.

摘要

血小板聚集实验证实了偏头痛患者和对照者血小板的5-羟色胺（5-HT）受体之间存在差异。然而，在利血平或氯丙嗪存在的情况下，未发现偏头痛患者和对照者血小板对5-HT的摄取存在差异。这些结果支持了以下假说：5-HT诱导血小板聚集的受体为引起血管收缩的血管受体提供了一个模型，并且与那些通过血小板膜转运5-HT的受体不同。

相似文献

1
Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.利血平和氯丙嗪对偏头痛患者及对照者血小板摄取5-羟色胺的影响。
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):711-4. doi: 10.1136/jnnp.37.6.711.
2
Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism.储存池病和白化病中血小板5-羟色胺（血清素）的研究。
J Clin Invest. 1974 Aug;54(2):421-33. doi: 10.1172/JCI107778.
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Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.麦角胺和甲基麦角新碱对偏头痛患者血小板聚集反应的影响。
J Neurol Neurosurg Psychiatry. 1974 May;37(5):593-7. doi: 10.1136/jnnp.37.5.593.
4
[Current concepts on the sorption, deposition and release of serotonin by blood platelets].[关于血小板对血清素的吸附、沉积和释放的当前概念]
Usp Sovrem Biol. 1973 May-Jun;75(3):379-87.
5
An assessment of platelet aggregation induced by 5-hydroxytryptamine.5-羟色胺诱导的血小板聚集评估。
J Clin Pathol. 1971 Apr;24(3):250-8. doi: 10.1136/jcp.24.3.250.
6
5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache.急性偏头痛患者的5-羟色胺水平及血小板聚集反应
J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):505-9. doi: 10.1136/jnnp.35.4.505.
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Pol J Pharmacol Pharm. 1988 Nov-Dec;40(6):691-5.
8
Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
9
Relationship between substances strengthening of the thrombocyte cell membrane on the aggregation of thrombocytes and on the uptake and release of serotonin.加强血小板细胞膜的物质与血小板聚集以及血清素摄取和释放之间的关系。
Acta Univ Carol Med Monogr. 1972;53:91-4.
10
5-Hydroxytryptamine uptake and release in relation to aggregation of rabbit platelets.5-羟色胺摄取与释放与兔血小板聚集的关系
J Physiol. 1969 Apr;201(2):409-23. doi: 10.1113/jphysiol.1969.sp008763.

本文引用的文献

1
5-Hydroxytryptamine in normal human platelets.正常人血小板中的5-羟色胺
J Physiol. 1955 Dec 29;130(3):711-20. doi: 10.1113/jphysiol.1955.sp005437.
2
D-receptor for serotonin on blood platelets.血小板上的5-羟色胺D受体。
Nature. 1969 Mar 29;221(5187):1253-4. doi: 10.1038/2211253a0.
3
Effects of 5-hydroxytryptamine on platelet aggregation.5-羟色胺对血小板聚集的影响。
Nature. 1968 Apr 13;218(5137):137-41. doi: 10.1038/218137a0.
4
An assessment of platelet aggregation induced by 5-hydroxytryptamine.5-羟色胺诱导的血小板聚集评估。
J Clin Pathol. 1971 Apr;24(3):250-8. doi: 10.1136/jcp.24.3.250.
5
Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid excretion in normal and migrainous subjects.正常人和偏头痛患者的血浆总血清素、5-羟吲哚乙酸及对羟基间甲氧基扁桃酸排泄情况。
Brain. 1965 Dec;88(5):997-1010. doi: 10.1093/brain/88.5.997.
6
Effects of methysergide on platelets incubated with reserpine.甲基麦角新碱对与利血平一起孵育的血小板的作用。
Br J Pharmacol. 1971 Aug;42(4):611-9. doi: 10.1111/j.1476-5381.1971.tb07145.x.
7
5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache.急性偏头痛患者的5-羟色胺水平及血小板聚集反应
J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):505-9. doi: 10.1136/jnnp.35.4.505.
8
Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.5-羟色胺及几种类似物对人体血小板的相对活性及摄取情况
Br J Pharmacol. 1972 Jan;44(1):117-39. doi: 10.1111/j.1476-5381.1972.tb07244.x.
9
Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.5-羟色胺在血小板中的代谢、转运与储存
Br J Pharmacol Chemother. 1968 Jan;32(1):1-16. doi: 10.1111/j.1476-5381.1968.tb00423.x.