利血平和氯丙嗪对偏头痛患者及对照者血小板摄取5-羟色胺的影响。
Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.
作者信息
Hilton B P
出版信息
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):711-4. doi: 10.1136/jnnp.37.6.711.
Abstract
Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascular receptors causing constriction and are distinct from those transferring 5-HT through the platelet membrane.
摘要
血小板聚集实验证实了偏头痛患者和对照者血小板的5-羟色胺（5-HT）受体之间存在差异。然而，在利血平或氯丙嗪存在的情况下，未发现偏头痛患者和对照者血小板对5-HT的摄取存在差异。这些结果支持了以下假说：5-HT诱导血小板聚集的受体为引起血管收缩的血管受体提供了一个模型，并且与那些通过血小板膜转运5-HT的受体不同。
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