豚鼠小肠下行抑制的神经机制。
A nervous mechanism for descending inhibition in guinea-pig small intestine.
作者信息
Hirst G D, McKirdy H C
出版信息
J Physiol. 1974 Apr;238(1):129-43. doi: 10.1113/jphysiol.1974.sp010514.
Abstract
- Intracellular recordings were made from neurones in the myenteric plexus of guinea-pig small intestine under conditions in which these neurones received synaptic input from an adjacent segment of intestine.2. Most long synaptic pathways in the myenteric plexus were found to lead in an anal direction.3. Such pathways could be excited by either distension or transmural electrical stimulation of the intestinal segment.4. Similar stimuli evoked inhibitory junction potentials in the circular muscle layer but only on the anal side of the stimulated region of intestine.5. The results are discussed in relation to the concept of descending inhibition (Bayliss & Starling, 1899).
摘要
在豚鼠小肠肌间神经丛神经元接受来自相邻肠段突触输入的条件下，进行细胞内记录。
发现肌间神经丛中的大多数长突触通路通向肛门方向。
此类通路可通过肠段的扩张或透壁电刺激来激发。
类似刺激在环形肌层诱发抑制性接头电位，但仅在受刺激肠段的肛门侧。
结合下行抑制概念（贝利斯和斯塔林，1899年）对结果进行了讨论。
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