Arkhipov V I, Azarashvili A A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Jul-Aug;29(4):745-50.
Rats placed in an experimental chamber, were trained to perform two dissociated reactions; the one--in a normal state, the other--after administration of physostigmine. Then the animals were divided into 10 groups and in each group the performance of the elaborated conditioned reflexes was tested after administration of the substances influencing cholinergic and monoaminergic brain systems. It is shown that the dissociation state after physostigmine administration is due to the influence of this substance on the cholinergic brain system. The increase of biogenic amines content in the central nervous system leads to the appearance of dissociation after a smaller dose of anticholinesterase. This seems to reflect a modulating influence of monoaminergic brain systems on the cholinergic system during performance of the dissociated reactions.
将大鼠置于实验箱中，训练它们执行两种分离反应；一种是在正常状态下，另一种是在给予毒扁豆碱后。然后将动物分成10组，在每组中，给予影响胆碱能和单胺能脑系统的物质后，测试所建立的条件反射的表现。结果表明，给予毒扁豆碱后的分离状态是由于该物质对胆碱能脑系统的影响。中枢神经系统中生物胺含量的增加会导致在较小剂量的抗胆碱酯酶作用后出现分离现象。这似乎反映了在执行分离反应过程中，单胺能脑系统对胆碱能系统的调节作用。
