[Role of the cholinergic and monoaminergic systems of the brain in dissociated learning].

Rats placed in an experimental chamber, were trained to perform two dissociated reactions; the one--in a normal state, the other--after administration of physostigmine. Then the animals were divided into 10 groups and in each group the performance of the elaborated conditioned reflexes was tested after administration of the substances influencing cholinergic and monoaminergic brain systems. It is shown that the dissociation state after physostigmine administration is due to the influence of this substance on the cholinergic brain system. The increase of biogenic amines content in the central nervous system leads to the appearance of dissociation after a smaller dose of anticholinesterase. This seems to reflect a modulating influence of monoaminergic brain systems on the cholinergic system during performance of the dissociated reactions.