评估人体皮肤局部用抗菌剂的方法。
Methods for evaluating topical antibacterial agents on human skin.
作者信息
Marples R R, Kligman A M
出版信息
Antimicrob Agents Chemother. 1974 Mar;5(3):323-9. doi: 10.1128/AAC.5.3.323.
Abstract
Three procedures were presented for appraising the ability of antibacterial chemicals and formulations to suppress the growth of microorganisms on human skin. In each of these, the microflora was quantified after the skin had been occlusively covered for a day or more, a circumstance which, in the absence of a deterrent, led to an explosive overgrowth by resident organisms. The data obtained related to (i) the capacity to prevent expansion of the normal microflora, (ii) the suppression of an already expanded flora, and (iii) the persistence of antibacterial effect 3 days after the last application.
摘要
介绍了三种评估抗菌化学品和配方抑制人体皮肤上微生物生长能力的方法。在每种方法中，在皮肤被封闭覆盖一天或更长时间后对微生物群落进行定量，在没有抑菌剂的情况下，这种情况会导致常驻微生物爆炸性过度生长。获得的数据涉及：（i）防止正常微生物群落扩张的能力；（ii）对已经扩张的微生物群落的抑制作用；（iii）最后一次应用后3天抗菌效果的持续性。
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