Bolton P M, James S L, Newcombe R G, Whitehead R H, Hughes L E
Gut. 1974 Mar;15(3):213-9. doi: 10.1136/gut.15.3.213.
Previous investigations of immune function in patients with Crohn's disease have yielded conflicting results. A comprehensive study of immune competence-peripheral lymphocyte count, serum immunoglobulin levels (IgG, IgA and IgM), lymphocyte response to PHA, Mantoux test, and DNCB response-has been performed in a large number of patients with inflammatory bowel disease. A total of 52 patients with Crohn's disease, 20 patients with ulcerative colitis, and 46 control patients with benign gastrointestinal disease were investigated. The patient groups were subdivided into ;well' and ;ill' in view of the differing clinical states of patients with inflammatory bowel disease. Some of the Crohn's and colitis patients were receiving steroid therapy. The peripheral blood lymphocyte count and lymphocyte response to PHA were similar in all patient groups. Serum IgA levels were elevated in Crohn's disease but fell significantly in ;ill' Crohn's patients following excisional surgery. Serum IgM levels rose significantly in ;ill' Crohn's patients after surgery. Steroid therapy was associated with diminution of both Mantoux and DNCB responses in the ;ill' Crohn's patients. There was no evidence of impairment of immune competence in either Crohn's disease or ulcerative colitis.
先前对克罗恩病患者免疫功能的研究结果相互矛盾。对大量炎症性肠病患者进行了一项关于免疫能力的综合研究，包括外周淋巴细胞计数、血清免疫球蛋白水平（IgG、IgA和IgM）、淋巴细胞对PHA的反应、结核菌素试验以及对二硝基氯苯的反应。共调查了52例克罗恩病患者、20例溃疡性结肠炎患者和46例患有良性胃肠道疾病的对照患者。鉴于炎症性肠病患者的临床状态不同，将患者组分为“病情良好”和“病情严重”两组。部分克罗恩病和结肠炎患者正在接受类固醇治疗。所有患者组的外周血淋巴细胞计数和淋巴细胞对PHA的反应相似。克罗恩病患者的血清IgA水平升高，但在“病情严重”的克罗恩病患者接受切除手术后显著下降。“病情严重”的克罗恩病患者术后血清IgM水平显著升高。类固醇治疗与“病情严重”的克罗恩病患者结核菌素试验和对二硝基氯苯反应的减弱有关。没有证据表明克罗恩病或溃疡性结肠炎患者存在免疫能力受损的情况。
