Wakelin D, Selby G R
Immunology. 1974 Jan;26(1):1-10.
Tolerance to the parasitic nematode was induced in mice by treatment with cortisone acetate given during the second week of a primary infection, the time at which the host is known to be beginning to respond to the antigens of the parasite. Continuation of the antigenic stimulus provided by infection beyond the period of immunosuppression was an essential requirement for tolerance; if the infection was terminated immediately after treatment the mice remained susceptible to subsequent infection, but then made a primary self-cure response. It is suggested that tolerance involves a long-lasting change in immunological reactivity of the host rather than a paralysis due to an excess of antigen, as tolerance was induced by small infections and persisted for at least 7 weeks in the absence of infection.
在初次感染的第二周，通过给予醋酸可的松对小鼠进行处理，诱导其对寄生线虫产生耐受性，已知宿主在这个时期开始对寄生虫抗原作出反应。在免疫抑制期之后，由感染提供的抗原刺激的持续存在是产生耐受性的一个基本要求；如果在处理后立即终止感染，小鼠仍易受随后的感染，但随后会作出初次自愈反应。有人提出，耐受性涉及宿主免疫反应性的长期变化，而不是由于抗原过量导致的麻痹，因为小剂量感染即可诱导耐受性，并且在没有感染的情况下耐受性至少持续7周。
