Wakelin D
Parasitology. 1975 Jun;70 Part 3:397-405. doi: 10.1017/s0031182000052173.
Immune serum accelerated the expulsion of Trichuris muris when transferred into normal mice on days 0 and 3 after infection, but had no effect when the recipient mice had been immunosuppressed by sublethal irradiation or by cortisone treatment. Delaying serum transfer until days 7 and 8 in normal mice failed to accelerate expulsion, although immune mesenteric lymph node cells (MLNC) accelerated expulsion whether transferred early or late in infection. Expulsion from NIH mice, normally complete by 12 days, was prevented by sublethal irradiation given as late as 9 days after infection, but could be restored by subsequent transfer of immune MLNC or, to a lesser degree, non-immune MLNC. Immune MLNC were unable to restore worm expulsion in mice irradiated before infection. These results are interpreted as showing that the immune expulsion of T. murius from mice during a primary infection requires the sequential activities of antibody-mediated and lymphoid cell-mediated components.
免疫血清在感染后第0天和第3天转移至正常小鼠体内时，可加速鼠鞭虫的排出，但当受体小鼠通过亚致死剂量照射或皮质酮处理而免疫抑制时则无作用。在正常小鼠中，将血清转移延迟至第7天和第8天未能加速排出，尽管免疫肠系膜淋巴结细胞（MLNC）无论在感染早期还是晚期转移均能加速排出。NIH小鼠通常在12天内完全排出，但在感染后第9天给予亚致死剂量照射可阻止排出，不过随后转移免疫MLNC或程度较轻的非免疫MLNC可恢复排出。免疫MLNC无法恢复感染前照射小鼠的驱虫作用。这些结果被解释为表明在初次感染期间从小鼠体内免疫排出鼠鞭虫需要抗体介导和淋巴细胞介导成分的顺序活动。
