Deykin E Y, MacMahon B
Am J Psychiatry. 1979 Oct;136(10):1310-2. doi: 10.1176/ajp.136.10.1310.
The authors examined 183 children with autistic symptoms and found that the age-specific incidence rates of seizures in this sample were between 3 and 28 times the rates for children in the general population. The subjects classified as totally autistic were at high risk of developing seizure from early childhood well into adolescence, but especially so at puberty. The partially autistic children had an increased risk of seizures only up to age 10. The authors suggest that the high incidence of seizures at puberty observed in this study may be specific to children with total autistic symptomatology and may represent a distinct pathological process associated with autism.
作者对183名有自闭症症状的儿童进行了检查，发现该样本中特定年龄的癫痫发病率是普通人群中儿童发病率的3至28倍。被归类为完全自闭症的受试者从幼儿期到青春期都有发生癫痫的高风险，尤其是在青春期。部分自闭症儿童只有在10岁之前癫痫发作风险增加。作者认为，本研究中观察到的青春期癫痫高发病率可能是完全自闭症症状儿童所特有的，可能代表了与自闭症相关的一种独特病理过程。
