Grosshans E, Dossmann L, Basset M
Ann Dermatol Venereol. 1979 Mar;106(3):259-64.
The median rhomboid glossitis is generally considered as a developmental anomaly of the tongue. Recent clinical, biological and experimental studies provide support for a fongous etiology: this lesion of the midline of the tongue is a chronic hyperplastic oral candidiasis, occurring sometimes in association with candidal commissural leukoplakias and palatine kissing lesions. The yeasts--mainly Candida albicans-- invade the upper parakeratotic layers of the epithelium inducing a proliferating acanthosis of the deeper epithelial ridges; superficial micro-pustules closely related to the candidal hyphae were found in most cases. Antifungal specific therapy appear effective in early lesions; later the condition becomes permanent and, in a few cases, may go further to malignant change. Fourteen cases are presented in this paper: the clinical, histopathological and therapeutic features are obviously in accord with this fongous infectious etiology (already suggested and demonstrated in 1965 by French stomatologists) and with the more recent experimental data published by Cawson, Sohnel and Kirkpatrick, Jones and Russell.
正中菱形舌炎通常被认为是舌的一种发育异常。近期的临床、生物学和实验研究支持其真菌病因：这种舌中线病变是一种慢性增生性口腔念珠菌病，有时与念珠菌性口角白斑和腭部接吻病变相关。酵母菌——主要是白色念珠菌——侵入上皮的表层不全角化层，导致更深层上皮嵴的增生性棘皮症；在大多数病例中发现了与念珠菌菌丝密切相关的浅表微脓疱。抗真菌特异性治疗在早期病变中似乎有效；后期病情会变为永久性，少数情况下可能进一步恶变。本文介绍了14例病例：临床、组织病理学和治疗特征明显符合这种真菌性感染病因（法国口腔学家在1965年已提出并证实）以及考森、索内尔和柯克帕特里克、琼斯和拉塞尔发表的最新实验数据。
