White R G, Herbert W J
Immunology. 1975 May;28(5):925-38.
Domestic fowl were found to be hypersensitive to a second injection of highly purified mineral oil if they had been primed 3 weeks previously with oil in the presence of mycobacteria. This response did not appear to be related to impurities originally present in the oil or introduced into it during sterilization, and did not follow priming with mycobacteria in vegetable oil or in saline. The reaction at the challenge site was prolonged and developed a characteristic histology identical to that found at the priming site. It is postualted that the hypersensitivity seen has an immunological basis and that birds are able to respond to antigenic determinants formed by long chain aliphatic hydrocarbons.
如果家鸡在3周前已在存在分枝杆菌的情况下用矿物油进行过初次免疫，那么它们会被发现对再次注射高纯度矿物油高度敏感。这种反应似乎与最初存在于油中或在灭菌过程中引入油中的杂质无关，并且在用植物油或盐水中的分枝杆菌进行初次免疫后不会出现。激发部位的反应持续时间延长，并形成了与初次免疫部位相同的特征性组织学表现。据推测，所观察到的超敏反应具有免疫学基础，并且鸟类能够对由长链脂肪烃形成的抗原决定簇作出反应。
