Pfitzer P, Pape H D
J Maxillofac Surg. 1975 Jun;3(2):119-24. doi: 10.1016/s0301-0503(75)80028-2.
DNA-histograms of smears of 11 plain leukoplakias, one of a precancerous leukoplakia, three of leukoplakia carcinoma in early stage, and one of a keratotic seqamous cell carcinoma of the floor of the mouth were prepared. The cell nuclei of the plain leukoplakia are mostly diploid, a small proportion has a DNA-content of 4 C. Intermediate values or polyploid nuclei are absent. In precancerous leukoplakia, intermediate values were noticed; in the cases of carcinoma in early stage, intermediate and polyploid nuclei were present, and in one case only polyploid nuclei. Only 2C and 4C nuclei occurred in a case of keratotic squamous cell carcinoma, which in comparison to earlier examined cases must be termed DNA negative.
制备了11例单纯性白斑、1例癌前白斑、3例早期白斑癌和1例口底角化性鳞状细胞癌涂片的DNA直方图。单纯性白斑的细胞核大多为二倍体，一小部分DNA含量为4C。不存在中间值或多倍体核。在癌前白斑中，发现了中间值；在早期癌病例中，存在中间值和多倍体核，仅1例为多倍体核。在1例角化性鳞状细胞癌中仅出现2C和4C核，与早期检查的病例相比，该病例必须称为DNA阴性。
