巨噬细胞相关抗原诱导迟发型超敏反应。巨噬细胞嗜细胞抗体的作用。
The induction of delayed hypersensitivity by macrophage-associated antigen. The role of macrophage cytophilic antibody.
作者信息
Zembala M, Ptak W, Hanczakowska M
出版信息
Immunology. 1974 Mar;26(3):465-76.
The regulation of the immune responses by antibody administered passively on peritoneal exudate cells (PEC) was studied in guinea-pigs. The immunogenicity of sheep red blood cells (SRBC) associated with PEC for the induction of delayed hypersensitivity (DH) to soluble erythrocyte antigen was enhanced when PEC were incubated with anti-SRBC antibody. In contrast, the antibody response to SRBC was depressed. This phenomenon was only observed with specific antibody and was partially blocked when PEC covered with anti-SRBC antibody were incubated with rabbit anti-guinea-pig globulin serum. Comparable amounts of anti-SRBC antibody injected separately had no enhancing effect. Anti-SRBC sera from which the cytophilic antibody activity had been removed were inactive. PEC-associated SRBC were usually more immunogenic than the same amount of `free' SRBC for the induction of delayed hypersensitivity and always more immunogenic for antibody production. These observations suggested that macrophage cytophilic antibody might be involved in the regulation of the immune response and play a role in the preferential induction of delayed hypersensitivity in the studied system.
在豚鼠中研究了被动给予抗体对腹腔渗出细胞（PEC）免疫反应的调节作用。当PEC与抗绵羊红细胞（SRBC）抗体孵育时，与PEC相关的SRBC对可溶性红细胞抗原诱导迟发型超敏反应（DH）的免疫原性增强。相反，对SRBC的抗体反应受到抑制。这种现象仅在特异性抗体存在时观察到，当用兔抗豚鼠球蛋白血清孵育覆盖有抗SRBC抗体的PEC时，该现象部分被阻断。单独注射等量的抗SRBC抗体没有增强作用。去除了嗜细胞抗体活性的抗SRBC血清没有活性。与PEC相关的SRBC在诱导迟发型超敏反应方面通常比等量的“游离”SRBC具有更强的免疫原性，并且在产生抗体方面总是具有更强的免疫原性。这些观察结果表明，巨噬细胞嗜细胞抗体可能参与免疫反应的调节，并在所研究的系统中在迟发型超敏反应的优先诱导中发挥作用。
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