小鼠肉瘤对单次和分次剂量X射线及快中子的反应。
The response of a mouse sarcoma to single and divided doses of x-rays and fast neutrons.
作者信息
Denekamp J
出版信息
Br J Cancer. 1974 Apr;29(4):292-9. doi: 10.1038/bjc.1974.69.
Abstract
The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray treatment, in contrast with rapidly shrinking carcinomata. Neutrons were approximately three times more effective than x-rays, both for single doses and for two fractions given in 48 hours, when regrowth was used as a measure of response. This observation is closely similar to results previously obtained on a rat fibrosarcoma and contrasts with previous results from a mouse mammary carcinoma, and is in agreement with the hypothesis.
摘要
为了验证以下假设，即与快速缩小的癌瘤相反，缓慢缩小的肉瘤再氧合能力较差，因此与分次X线治疗相比，分次中子治疗对其更有益，我们研究了一种实验性肉瘤对单次剂量以及两部分X线和快中子的反应。当将再生长用作反应的衡量指标时，无论是单次剂量还是在48小时内给予的两部分剂量，中子的效果约为X线的三倍。这一观察结果与先前在大鼠纤维肉瘤上获得的结果非常相似，与先前在小鼠乳腺癌上的结果形成对比，并且与该假设相符。
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An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy.一种用于比较动物体内完整恶性肿瘤治疗方法及其在放射治疗中氧气应用的实验方法。
Br J Cancer. 1960 Sep;14(3):555-76. doi: 10.1038/bjc.1960.62.
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The relative effects of fast neutrons and x rays on tumour and normal tissue in the rat. I. Single doses.快中子和X射线对大鼠肿瘤及正常组织的相对效应。I. 单次剂量。
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