Welch B L, Hendley E D, Turek I
Science. 1974 Jan 18;183(4121):220-1. doi: 10.1126/science.183.4121.220.
Membrane affinity for the neurotransmitter norepinephrine is rapidly but reversibly decreased in nerve terminals of the cerebral cortex by intense nervous stimulation. This should adaptively facilitate alerting during acute emergency and stress. The Michaelis constant (K(m)) for the high-affinity active uptake of norepinephrine into crude synaptosome-rich homogenates of the cerebral cortices of mice was increased 68 percent after 15 minutes of intense fighting and 110 percent 5 minutes after a single electroconvulsive shock. These changes were no longer evident 18 to 20 hours later.
在大脑皮层的神经末梢中，通过强烈的神经刺激，对神经递质去甲肾上腺素的膜亲和力会迅速但可逆地降低。这应该会在急性紧急情况和应激期间适应性地促进警觉。在小鼠大脑皮层富含粗突触体的匀浆中，去甲肾上腺素高亲和力主动摄取的米氏常数（K(m)）在激烈打斗15分钟后增加了68%，在单次电惊厥休克5分钟后增加了110%。这些变化在18至20小时后不再明显。
