Skurygin V P
Vopr Med Khim. 1995 May-Jun;41(3):39-41.
Acute stress was simulated in Wistar rats by means of uncontrolled electric shock within 6 hrs; chronic stress, after the first 6-hr course, was developed within 9 days using 1-h daily treatment. Within 18 hrs of the acute stress occurring concentration of serotonin was decreased 2-fold in tissues of brain cortex, while reverse absorption of the neurotransmitter in synaptosomes was increased 3-fold. Under conditions of chronic stress concentration of serotonin tend to increase, whereas reverse absorption by nerve endings was decreased, which appear to occur due to brain adaptation to chronic stress.
通过在6小时内进行无控制电击来模拟Wistar大鼠的急性应激；在第一个6小时疗程后，通过每天1小时的治疗，在9天内产生慢性应激。在急性应激发生后的18小时内，大脑皮质组织中血清素的浓度降低了2倍，而神经突触小体中神经递质的反向吸收增加了3倍。在慢性应激条件下，血清素浓度趋于升高，而神经末梢的反向吸收则降低，这似乎是由于大脑对慢性应激的适应所致。
