青霉胺的骨髓毒性
Myelotoxicity of D-penicillamine.
作者信息
Kay A G
出版信息
Ann Rheum Dis. 1979 Jun;38(3):232-6. doi: 10.1136/ard.38.3.232.
Abstract
Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded blood counts on at least 5 of the patients showed a downward trend of the white cell and platelet counts while D-penicillamine was still being administered. One patient suddenly developed leucopenia and thrombocytopenia with a streptococcal septicaemia.
摘要
已收集了10例患者的信息，其中9例有骨髓抑制，1例诊断为疑似。10例患者中有6例死亡。至少5例患者连续记录的血细胞计数显示，在仍在服用青霉胺时，白细胞和血小板计数呈下降趋势。1例患者突然出现白细胞减少和血小板减少，并伴有链球菌败血症。
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