青霉胺治疗类风湿关节炎导致的致命性再生障碍性贫血和肝毒性。
Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.
作者信息
Fishel B, Tishler M, Caspi D, Yaron M
机构信息
Department of Rheumatology, Ichilov Hospital, Tel Aviv Medical Center, Israel.
出版信息
Ann Rheum Dis. 1989 Jul;48(7):609-10. doi: 10.1136/ard.48.7.609.
Abstract
A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.
摘要
一名65岁的类风湿性关节炎女性因服用D-青霉胺而出现骨髓再生障碍和黄疸。骨髓恢复无效，尽管采取了强化治疗措施，患者最终还是死亡。本文介绍并讨论了这种罕见的骨髓毒性和肝毒性并存的情况。
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Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.青霉胺治疗类风湿关节炎导致的致命性再生障碍性贫血和肝毒性。
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本文引用的文献
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RHEUMATOID ARTHRITIS WITH ARTERITIS; REPORT OF A CASE TREATED WITH PENICILLAMINE.类风湿关节炎合并动脉炎；青霉胺治疗病例报告
Ann Intern Med. 1964 Sep;61:556-63. doi: 10.7326/0003-4819-61-3-556.
2
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.类风湿关节炎患者使用青霉胺相关的肝毒性。
Ann Rheum Dis. 1980 Apr;39(2):152-4. doi: 10.1136/ard.39.2.152.
3
D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3.青霉胺诱导的类风湿关节炎毒性：硫氧化状态和HLA-DR3的作用
J Rheumatol. 1984 Oct;11(5):626-32.
4
Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs.类风湿病的遗传基础：HLA抗原、疾病表现及对药物的毒性反应。
Br Med J. 1978 Nov 11;2(6148):1326-8. doi: 10.1136/bmj.2.6148.1326.
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Br Med J. 1978 Jul 8;2(6130):91. doi: 10.1136/bmj.2.6130.91.
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Bull Rheum Dis. 1977;28(6):948-52.
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Cholestatic jaundice caused by D-penicillamine.青霉胺引起的胆汁淤积性黄疸。
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8
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