Hakala T R, Lange P H
Science. 1974 May 17;184(4138):795-7. doi: 10.1126/science.184.4138.795.
In some serums of patients with transitional cell carcinoma (TCC), a factor is present which induces lymphocytes from most donors with or without TCC to become cytotoxic against TCC-derived target cells. The induced cytotoxicity was directed against target cells derived from TCC's of the renal pelvis, ureter, and urinary bladder, but not against cells derived from normal kidney, bladder, testis, or skin or from renal cell carcinoma. Cytotoxicity occurred without complement but did not occur without effector cells.
在一些移行细胞癌（TCC）患者的血清中，存在一种因子，该因子可诱导大多数患有或未患有TCC的供体的淋巴细胞对TCC来源的靶细胞产生细胞毒性。诱导的细胞毒性针对来自肾盂、输尿管和膀胱的TCC的靶细胞，但不针对来自正常肾脏、膀胱、睾丸或皮肤或肾细胞癌的细胞。细胞毒性在没有补体的情况下发生，但没有效应细胞则不会发生。
