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免疫及非免疫外周淋巴细胞对包被有细菌外单位膜的靶细胞的免疫血浆依赖性细胞毒性。

Immune plasma-dependent cytotoxicity of immune and non-immune peripheral lymphoid cells for target cells coated with bacterial outer unit membrane.

作者信息

Torten M, Johnson R C, Kaattari S, Leung C, Benjamini E

出版信息

Immunology. 1975 Dec;29(6):1093-102.

PMID:1193683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1446022/
Abstract

The development of a model system for use in the study of lymphoid cell cytotoxicity to bacterial membrane antigens was attempted. In this system 51 Cr-labelled chicken red blood target cells were coated with pieces of the outer unit membrane of leptospirae rather than with soluble antigens. Using the model system to study dog peripheral immune lymphoid cell cytotoxicity to coated target cells we found that both immune and non-immune lymphocytes are antibody dependent for the expression of their cytotoxicity. It was also found that the unit membrane preparation from leptospirae can serve as a good antigenic stimulant to immune dog lymphoid cells as measured by increased [3H]thymidine uptake.

摘要

尝试开发一种用于研究淋巴样细胞对细菌膜抗原细胞毒性的模型系统。在该系统中，用钩端螺旋体外层单位膜碎片而非可溶性抗原包被51 Cr标记的鸡红细胞靶细胞。利用该模型系统研究犬外周免疫淋巴样细胞对包被靶细胞的细胞毒性，我们发现免疫和非免疫淋巴细胞的细胞毒性表达均依赖抗体。还发现，通过增加的[3H]胸苷摄取量来衡量，钩端螺旋体的单位膜制剂可作为免疫犬淋巴样细胞的良好抗原刺激物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1055/1446022/4f23bfca28f9/immunology00311-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1055/1446022/d88baeabb8a3/immunology00311-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1055/1446022/4f23bfca28f9/immunology00311-0142-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1055/1446022/d88baeabb8a3/immunology00311-0141-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1055/1446022/4f23bfca28f9/immunology00311-0142-a.jpg

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Immune plasma-dependent cytotoxicity of immune and non-immune peripheral lymphoid cells for target cells coated with bacterial outer unit membrane.免疫及非免疫外周淋巴细胞对包被有细菌外单位膜的靶细胞的免疫血浆依赖性细胞毒性。
Immunology. 1975 Dec;29(6):1093-102.
2
Proceedings: Immune plasma-dependent cytotoxicity of immune and nonimmune peripheral lymphoid cells to target cells coated with bacterial outer unit membrane.论文集：免疫和非免疫外周淋巴细胞对包被有细菌外单位膜的靶细胞的免疫血浆依赖性细胞毒性
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本文引用的文献

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Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes.纯化淋巴细胞对抗体包被的鸡红细胞的接触性溶解作用。
Cell Immunol. 1970 Sep;1(3):300-15. doi: 10.1016/0008-8749(70)90051-1.
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Antibody-mediated target cell lysis by non-immune cells. Characterization of the antibody and effector cell populations.非免疫细胞介导的抗体依赖性靶细胞裂解。抗体和效应细胞群体的特征分析。
Eur J Immunol. 1972 Oct;2(5):419-24. doi: 10.1002/eji.1830020507.
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Simplified whole blood method for evaluating in vitro lymphocyte reactivity of laboratory animals.
牛体内抗体依赖性细胞介导的细胞毒性：针对包被原生动物抗原的51Cr标记鸡红细胞的活性。
Infect Immun. 1978 Nov;22(2):492-501. doi: 10.1128/iai.22.2.492-501.1978.
评价实验动物体外淋巴细胞反应性的简化全血法
Clin Exp Immunol. 1972 May;11(1):137-42.
4
Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes.抗体依赖性淋巴细胞介导的细胞毒性：无需胸腺衍生淋巴细胞。
Science. 1972 Jan 14;175(4018):194-6. doi: 10.1126/science.175.4018.194.
5
Lysis of chicken erythrocytes sensitized with PPD by lymphoid cells from guinea pigs immunized with tubercle bacilli.用结核杆菌免疫的豚鼠的淋巴细胞对用PPD致敏的鸡红细胞的溶解作用。
Int Arch Allergy Appl Immunol. 1970;38(2):204-16. doi: 10.1159/000230273.
6
Serum induced lymphoid cell mediated cytotoxicity to human transitional cell carcinomas of the genitourinary tract.血清诱导的淋巴细胞介导的对人泌尿生殖道移行细胞癌的细胞毒性。
Science. 1974 May 17;184(4138):795-7. doi: 10.1126/science.184.4138.795.
7
Immunogenic properties of a leptospiral outer envelope bacterin in hamsters and foxes.钩端螺旋体外膜菌苗在仓鼠和狐狸体内的免疫原性
Am J Vet Res. 1974 May;35(5):681-4.
8
Isolation of the outer sheath of Leptospira and its immunogenic properties in hamsters.钩端螺旋体外膜的分离及其在仓鼠中的免疫原性特性
Infect Immun. 1972 Jun;5(6):968-75. doi: 10.1128/iai.5.6.968-975.1972.
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Lymphoid cell-mediated antibody-dependent cytotoxicity in untreated and bursectomized chickens.未处理和法氏囊切除鸡中淋巴细胞介导的抗体依赖性细胞毒性
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Antibody-mediated target cell lysis by nonimmune cells: the use of anti-immunoglobulin to distinguish effector cell population.非免疫细胞介导的抗体依赖性靶细胞裂解：利用抗免疫球蛋白区分效应细胞群体。
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