Carp J S, Anderson R J
Arch Int Pharmacodyn Ther. 1979 Jan;237(1):139-48.
Adult cats were monitored for their performance of a variety of motor functions before and after acute administration of phenytoin (5, 10 or 20 mg/kg) in a schedule in which each animal received all drug doses. The only significant loss in motor function was balance and coordination. Half the animals could not balance or walk along a narrow-edged beam after 20 mg/kg of phenytoin although their performance was not impaired at lower drug doses or on wider surfaces. There were no effects of phenytoin on the righting reflex, flexor reflex, muscle strength, the hopping response, the blind placing response or visually aided placing. The data suggest that phenytoin has a selective effect on higher order neuronal systems involved with balance and locomotion rather than simple reflex pathways.
对成年猫在急性给予苯妥英钠（5、10或20毫克/千克）之前和之后的各种运动功能表现进行监测，给药方案是每只动物接受所有剂量的药物。运动功能方面唯一显著的损失是平衡和协调能力。给予20毫克/千克苯妥英钠后，一半的动物无法在窄边梁上保持平衡或行走，尽管在较低药物剂量或在更宽的表面上其表现未受损害。苯妥英钠对翻正反射、屈肌反射、肌肉力量、跳跃反应、盲目放置反应或视觉辅助放置均无影响。数据表明，苯妥英钠对参与平衡和运动的高阶神经元系统有选择性作用，而非简单的反射通路。
