De Groot C A, Tijssen A M
Arch Int Pharmacodyn Ther. 1981 Sep;253(1):137-47.
The previous finding that chlorothiazide (about 250 mg/day) induces a sustained reduction in the polyuria of homozygous Brattleboro (BB) female rats, as well as an increase to about 250% of plasma renin activity was confirmed. Disruption of the renin-angiotensin system by either the angiotensin antagonist saralasin or the beta-blocking agent propranolol does not interfere with chlorothiazide antidiuresis. Each inhibitor reduces BB polyuria on its own, an effect which, however, may be explained by a possible interference with thirst.
先前的研究发现得到了证实，即氯噻嗪（约250毫克/天）可使纯合布拉特洛伯勒（BB）雌性大鼠的多尿症持续减轻，同时血浆肾素活性增加至约250%。血管紧张素拮抗剂沙拉新或β受体阻滞剂普萘洛尔对肾素-血管紧张素系统的干扰并不影响氯噻嗪的抗利尿作用。每种抑制剂自身均可减轻BB大鼠的多尿症，然而，这一作用可能是由于对口渴的干扰所致。
