Saito I, Misumi J, Kondo K, Saruta T, Matsuki S
Cardiovasc Res. 1976 Mar;10(2):149-52. doi: 10.1093/cvr/10.2.149.
Short (2 weeks) and long (12 weeks) term effects of furosemide and chlorothiazide on blood pressure, plasma renin activity, and uric acid concentration were studied in 69 hypertensive patients. Both treatments caused significant reductions in blood pressure and increases in plasma renin activity and uric acid at 2 and 12 weeks in 6) normal renin patients; there was no difference between the effects of furosemide and that of chlorothiazide. Reduction in blood pressure in eight low renin patients who showed smaller changes in plasma renin activity and uric acid was not significant at 2 weeks but significant after 12 weeks of treatment.
对69例高血压患者研究了速尿和氯噻嗪对血压、血浆肾素活性及尿酸浓度的短期（2周）和长期（12周）影响。两种治疗方法在60例正常肾素患者中均使2周和12周时血压显著降低，血浆肾素活性及尿酸升高；速尿和氯噻嗪的效果无差异。8例低肾素患者血浆肾素活性及尿酸变化较小，其血压在治疗2周时降低不显著，但在12周治疗后显著降低。
