Mishalany H G, Nakada K, Woolley M M
Arch Surg. 1979 Oct;114(10):1118-23. doi: 10.1001/archsurg.1979.01370340024003.
Fifty-five patients with congenital diaphragmatic hernias (1966 to 1976) were studied and compared to 65 similar patients reported previously (1953 to 1963). The mortality was found to be the same in the two groups despite the fact that in the current series, patients were diagnosed and operated on at a younger age. Initial uncorrected pH value was found to be of prognostic importance. All babies whose initial uncorrected pH was greater than 7.0 survived and almost all those whose pH was less than 7.0 died, with the group in-between having a 50% chance of survival. Earlier operation and correction of acidosis did not substantially improve the chance of survival. Hypoplasia of the lungs and major cardiovascular anomalies contributed to death in a number of patients. Pulmonary hypertension causing a right-to-left shunt was responsible for the deaths of others and, therefore, the use of vasodilator drugs deserves further evaluation.
对55例先天性膈疝患者（1966年至1976年）进行了研究，并与之前报道的65例类似患者（1953年至1963年）进行了比较。尽管在当前系列中患者在更年轻的时候被诊断并接受手术，但发现两组的死亡率相同。发现初始未校正的pH值具有预后重要性。所有初始未校正pH大于7.0的婴儿均存活，而几乎所有pH小于7.0的婴儿均死亡，介于两者之间的组有50%的存活机会。早期手术和酸中毒的纠正并没有显著提高存活几率。肺部发育不全和主要心血管异常导致了一些患者死亡。导致右向左分流的肺动脉高压是其他患者死亡的原因，因此，血管扩张剂药物的使用值得进一步评估。
