A、B和Lewis血型抗原与癌胚抗原（CEA）相关性的研究。
Studies of the association of the A, B and Lewis Blood group antigens with carcinoembryonic antigen (CEA).
作者信息
Holburn A M, Mach J P, MacDonald D, Newlands M
出版信息
Immunology. 1974 Apr;26(4):831-43.
Abstract
Carcinoembryonic antigen (CEA) was purified from primary tumour or from hepatic metastases obtained from ten cases of carcinoma of the colon. In nine cases the blood group antigens A, B, Le or Le were detected in CEA preparations by the binding of I-labelled CEA by blood group antibodies. The extent of binding appeared to preclude simple contamination of CEA preparations by blood group glycoprotein. In all cases the blood group antigens detected were consistent with the patients' known blood groups. Blood group I and i activities were not detected. It is concluded that the determinants of A, B and Lewis antigens and of CEA share the same glycoprotein carrier molecules.
摘要
癌胚抗原（CEA）是从10例结肠癌患者的原发性肿瘤或肝转移灶中纯化得到的。在9例中，通过血型抗体与碘标记的CEA结合，在CEA制剂中检测到血型抗原A、B、Le或Le。结合程度似乎排除了血型糖蛋白对CEA制剂的简单污染。在所有病例中，检测到的血型抗原与患者已知的血型一致。未检测到血型I和i活性。结论是，A、B和Lewis抗原以及CEA的决定簇共享相同的糖蛋白载体分子。
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