人绒毛膜促性腺激素β亚基抑制对促黄体激素的类固醇生成反应的能力。
Ability of human chorionic gonadotropin beta-subunit to inhibit the steroidogenic response to lutropin.
作者信息
Dighe R R, Muralidhar K, Moudgal N R
出版信息
Biochem J. 1979 Jun 15;180(3):573-8. doi: 10.1042/bj1800573.
Ability of the beta-subunit of human chorionic gonadotropin to inhibit the response to lutropin (luteinizing hormone, LH) was tested in the immature rat ovarian system and pregnant-mare-serum-gonadotropin-primed rat ovarian system with progesterone production being used as the response. Human chorionic gonadotropin beta-subunit was found to inhibit human and ovine lutropin-stimulated progesterone production. At a constant dose of lutropin, inhibition was dependent on the concentration of beta-subunit. When concentration of the beta-subunit was kept constant at 5.0 microgram/ml and the concentration of lutropin was varied, the inhibition was maximum at the saturating concentration of the native hormone. The alpha-subunit of the human chorionic gonadotropin did not inhibit the response to lutropin. The lutropin/beta-subunit ratio required to produce an inhibition of response was much lower than that required to bring about an observable inhibition of binding.
在未成熟大鼠卵巢系统以及经孕马血清促性腺激素预处理的大鼠卵巢系统中，以孕酮生成作为反应指标，测试了人绒毛膜促性腺激素β亚基抑制对促黄体素（促黄体生成素，LH）反应的能力。结果发现，人绒毛膜促性腺激素β亚基可抑制人促黄体素和羊促黄体素刺激的孕酮生成。在促黄体素剂量恒定的情况下，抑制作用取决于β亚基的浓度。当β亚基浓度保持在5.0微克/毫升不变而改变促黄体素浓度时，在天然激素的饱和浓度下抑制作用最大。人绒毛膜促性腺激素的α亚基不抑制对促黄体素的反应。产生反应抑制所需的促黄体素/β亚基比值远低于引起可观察到的结合抑制所需的比值。
Zotero 插件