肝素抗凝活性的分子量依赖性
On the molecular-weight-dependence of the anticoagulant activity of heparin.
作者信息
Thunberg L, Lindahl U, Tengblad A, Laurent T C, Jackson C M
出版信息
Biochem J. 1979 Jul 1;181(1):241-43. doi: 10.1042/bj1810241.
Abstract
The inactivation of thrombin and factor Xa by antithrombin was determined in the presence of heparin fractions of different molecular weights and with high affinity for antithrombin. The ability to potentiate the inactivation of either coagulation factor increased with increasing length of the polysaccharide chain.
摘要
在存在不同分子量且对抗凝血酶具有高亲和力的肝素片段的情况下，测定了抗凝血酶对凝血酶和Xa因子的灭活作用。增强任一凝血因子灭活作用的能力随着多糖链长度的增加而增强。
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本文引用的文献
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Studies on bovine factor X. II. Characterization of purified factor X. Observations on some alterations in zone electrophoretic and chromatographic behavior occurring during purification.牛凝血因子X的研究。II. 纯化的凝血因子X的特性。关于纯化过程中区域电泳和色谱行为某些变化的观察。
Biochemistry. 1968 Dec;7(12):4506-17. doi: 10.1021/bi00852a047.
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Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.肝素的抗凝活性：通过固定化抗凝血酶亲和色谱法分离高活性和低活性肝素种类
FEBS Lett. 1976 Jul 1;66(1):90-3. doi: 10.1016/0014-5793(76)80592-3.
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