Astor M, Hall E J
Br J Cancer. 1979 May;39(5):510-5. doi: 10.1038/bjc.1979.94.
A combination of misonidazole and MTDQ (6,6'-methylene-bis-2,2,4 trimethyl-1,2-dihydroquinoline) has been tested for its radiation-sensitizing properties and cytotoxicity, using Chinese hamster V79 cells cultured in vitro. Both compounds sensitize hypoxic cells to the effects of X-rays, and when used in combination their sensitizing properties are additive. By contrast, the presence of MTDQ completely inhibits the cytotoxicity that misonidazole exhibits towards hypoxic cells. These experiments shed some light on the mechanism of action of electron-affinic hypoxic cell sensitizers, and the combination of radiosensitizers suggested may have an application in human cancer radiotherapy by eliminating the neurotoxicity experienced by patients receiving misonidazole during radiotherapy.
已使用体外培养的中国仓鼠V79细胞，对米索硝唑和MTDQ（6,6'-亚甲基双-2,2,4-三甲基-1,2-二氢喹啉）的组合进行了辐射增敏特性和细胞毒性测试。两种化合物均能使缺氧细胞对X射线的作用敏感，并且当联合使用时，它们的增敏特性具有相加性。相比之下，MTDQ的存在完全抑制了米索硝唑对缺氧细胞表现出的细胞毒性。这些实验为亲电子性缺氧细胞增敏剂的作用机制提供了一些线索，并且所建议的放射增敏剂组合可能通过消除放疗期间接受米索硝唑治疗的患者所经历的神经毒性，而应用于人类癌症放疗。
