Marshall R C, Brookes L G, du Vivier A
Br J Dermatol. 1979 Aug;101(2):163-6. doi: 10.1111/j.1365-2133.1979.tb05602.x.
An animal model for investigating topically applied epidermal cytotoxic drugs to determine optimum therapeutic doses and schedules is described. It is used here to examine the effects of cycloheximide on epidermal DNA synthesis, as measured by 3H-thymidine incorporation in vivo, in terms of dose/response and activity/time profiles and potential systemic toxicity.
本文描述了一种用于研究局部应用表皮细胞毒性药物以确定最佳治疗剂量和给药方案的动物模型。在此，该模型用于研究环己酰亚胺对表皮DNA合成的影响，具体通过体内3H-胸腺嘧啶核苷掺入来测量，研究内容包括剂量/反应和活性/时间曲线以及潜在的全身毒性。
