du Vivier A, Marshall R C, Brookes L G
Br J Dermatol. 1978 Feb;98(2):209-15. doi: 10.1111/j.1365-2133.1978.tb01624.x.
A simple animal model for studying topically applied glucocorticosteroids for their effect on epidermal DNA synthesis is described. It is designed so that their potential for systemic side effects may be predicted and its usefulness in this respect is illustrated by the results obtained with two of the steroids investigated. One, a new formulation Temetex, is predicted to have considerable systemic potential. The other, Molivate, is remarkable for having moderate local, without demonstrable systemic activity.
本文描述了一种用于研究局部应用糖皮质激素对表皮DNA合成影响的简单动物模型。该模型的设计目的是预测其产生全身副作用的可能性，并且通过对两种所研究的类固醇药物的实验结果说明了该模型在这方面的实用性。其中一种新配方Temetex预计具有相当大的全身副作用可能性。另一种药物Molivate则因其局部作用适中且无明显全身活性而引人注目。
