Lancelot G, Mayer R, Hélène C
Biochim Biophys Acta. 1979 Sep 27;564(2):181-90. doi: 10.1016/0005-2787(79)90217-x.
Complex formation between the side chain of arginine and nucleic acid bases has been investigated by proton magnetic resonance in dimethylsulfoxide. Simultaneous formation of two hydrogen bonds leads to a selectivity of arginine interaction towards cytosine and guanine. A comparison is made of the interaction of arginine side chain with nucleic acid bases, phosphate and carboxylate anions. It is shown that interaction between carboxylate and arginine is stronger than between phosphate and arginine. These results are discussed with respect to the selective recognition of nucleic acid bases by arginine side chains and by the arginyl-glutamyl ion pair which could form in proteins interacting with nucleic acids.
通过在二甲基亚砜中的质子磁共振研究了精氨酸侧链与核酸碱基之间的复合物形成。两个氢键的同时形成导致精氨酸与胞嘧啶和鸟嘌呤相互作用的选择性。对精氨酸侧链与核酸碱基、磷酸根和羧酸根阴离子的相互作用进行了比较。结果表明，羧酸根与精氨酸之间的相互作用强于磷酸根与精氨酸之间的相互作用。就精氨酸侧链以及在与核酸相互作用的蛋白质中可能形成的精氨酰-谷氨酰离子对选择性识别核酸碱基这一点对这些结果进行了讨论。
